For many of these side effects, it was not clear if they were due to lamivudine, zidovudine, the other drugs used to treat hiv infection, or the underlying disease process. Zidovudine side effects as reported by black, hispanic, and whitenonhispanic patients with early hiv disease. This medicine can lower, but not fully prevent, the risk of spreading hiv to others. As mentioned earlier, nrtis such as zidovudine azt, stavudine d4t have been widely used in treatment of hiv infection but have undesirable adverse side effects. To learn more about possible side effects of zidovudine, read the drug label or package insert or talk to your health care provider or pharmacist. Methadone effects on zidovudine disposition aids clinical. These effects resulted primarily from inhibition of zdv glucuronidation, but also from decreased renal clearance of zdv. Zidovudine investigated as a drug, mutagen, reproductive effector, and tumorigen. Maintain balanced nutrition including weight at expected levels. If you notice anything unusual and are concerned, contact your doctor.
Find patient medical information for zidovudine oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Includes common and rare side effects information for consumers and. Many side effects from hiv medicines, such as nausea or occasional dizziness, are manageable. Find information on zidovudine retrovir in daviss drug guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Dosing information, drug interactions, and pregnancy information are included. Zidovudine has been shown in clinical trials to prolong survival of patients with acquired immune deficiency syndrome aids and advanced aidsrelated complex arc, and to delay progression to arc or aids in. Early upper digestive tract side effects of zidovudine. Zidovudine for treatment of hiv infection this leaflet is about the use of. Zidovudine controls hiv infection but does not cure it. Admet data is predicted using admetsar, a free tool for evaluating. Of these tablets in renal functions also i read too much from medical sites.
Because drug effects may differ among individuals from different racial and ethnic backgrounds, we undertook a post hoc analysis of two of the largest placebocontrolled trials of zidovudine therapy for hiv disease to determine whether the subjective side effects of zidovudine differ among patients of black, hispanic, or whitenonhispanic origin. Zidovudine side effects, dosage, interactions drugs everyday health search. However, many people have no side effects or only have minor side effects. Less common side effects include faint discoloration of fingernails and toenails, mood elevation, occasional tingling or transient numbness of the hands or feet, and. Zidovudine uses, side effects, substitutes, composition. Azt zidovudine, sold under the brand name retrovir, is a type of antihiv antiretroviral drug called a nucleoside analogue. Zidovudine side effects as reported by black, hispanic. Pdf zidovudine was the first agent approved for treatment of hiv disease, and. Introduction zidovudine or azt azidothymidine is the drug used to delay development of aids acquired immunodeficiency syndrome in patients infected with hiv human immunodeficiency virus.
Several fdaapproved drug labels may be available for zidovudine. In addition, low grade fever and muscle aches may occur. There may, sometimes, be other sideeffects that are not listed above. Our retrovir zidovudine side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Consumer information about the medication zidovudine azt oral retrovir, includes side effects, drug interactions, recommended dosages, and storage information. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away. Retrovir zidovudine is not the first choice to treat hiv because of its side effects. Common side effects of hiv medicines american family physician. Azt belongs to a group of drugs known as nucleoside reverse transcriptase inhibitors nrtis. Patients who receive both methadone and zidovudine may experience symptoms characteristic of opiate withdrawal and attribute the cause to decreased methadone levels due to zidovudine.
However, it is more likely patients are actually experiencing zidovudine side effects due to increased levels since zidovudine has no effect on methadone metabolism. Lamivudine and zidovudine is a combination medicine used to treat. It acts by interfering with viral reverse transcriptase, thereby inhibiting human immunodeficiency virus hiv replication. It is a combination of two antiretroviral medications, lamivudine and zidovudine. However, when used separately, the two drugs can have serious side effects in some patients. Some side effects of zidovudine may occur that usually do not need medical attention. Zidovudine after occupational exposure to hiv article pdf available in bmj clinical research 3036808. Serious side effects of zidovudine include lactic acidosis, liver problems, myopathy.
Patient goals and expected outcomes the patient will. Zidovudine was the first medication approved for the treatment of hiv and aids. Inclusion or absence of a drug label on the aidsinfo site does not imply endorsement or lack thereof by aidsinfo. Prescribing information lamivudine 150 mgzidovudine 300. Zidovudine definition of zidovudine by medical dictionary. Most common sideeffects include nausea, vomiting, acid reflux heartburn, headache, cosmetic reduction in abdominal body fat, light sleeping, and loss of appetite. Retrovir zidovudine can cause serious blood, muscle, and liver problems. Tell your doctor if you have or have ever had a low number of any type of blood cells or any blood disorders such as anemia a lower than normal number of red blood cells or. The risk or severity of adverse effects can be increased when zidovudine is. Lamivudine and zidovudine are antiviral medications that prevent human immunodeficiency virus hiv from multiplying in your body. Zidovudine is a dideoxynucleoside analogue of thymidine. You can report side effects to fda at 1800fda1088 18003321088 or online. No adverse effects were reported on maternal body weight, food consump. Stavudine, zidovudine, tenofovir, abacavir, emtricitabine brand name.
Emphasize the importance of compliance with therapy, not taking more than prescribed amount, and not. Feel free to talk with your doctor about your current and future treatment options. Lamivudine zidovudine audio icon audio icon brand name. In 1987 azt became the first drug to be approved by the u. Department of medicine, klinikum steglitz, free university of berlin, and department of medicine. Please do not stop zidovudine without talking to your doctor first. Azt zidovudine, retrovir catie canadas source for hiv and. See related article on adverse effects of antiretroviral therapy for hiv. Only select registry of toxic effects of chemical substances rtecs data is presented here. Zidovudine for the prevention of hiv transmission from. The effect of food was not assessed for the lamivudinezidovudine tablets co. Zidovudine zdv, also known as azidothymidine azt, is an antiretroviral medication used to. The most common side effects of azt can include headache, nausea, and loss of appetite. Emphasize the importance of taking zidovudine as directed even if the patient is asymptomatic, and that this drug must always be used in combination with other antiretroviral drugs.
See actual entry in rtecs for complete information. What are some other side effects of zidovudine injection. See the aidsinfo fact sheet on hiv medicines and side effects for more information. Zidovudine can suppress bone marrow production of blood cells hematologic toxicity, resulting in anemia or neutropenia. Your doctor will discuss these with you before you start treatment.
Do not take more than prescribed amount, and do not stop taking without consulting health care professional. This indicated that saquinavirloaded chitosan nanoparticles exhibited better cell uptake than the free drugs. Zidovudine zidovudine dose, indications, adverse effects. Zidovudine for treatment of hiv infection medicines for. These side effects may go away during treatment as your body adjusts to the medicine. Lamivudine and zidovudine may decrease the number of certain cells in your blood, including red and white blood cells. Jacobson ma, gundacker h, hughes m, fischl m, volberding p. Doctors give trusted answers on uses, effects, sideeffects, and cautions. Do not take more or less of it or take it more often than prescribed by your doctor. Call your doctor for medical advice about side effects. This study confirms that methadonemaintained patients receiving standard zdv doses experience greater zdv exposure and may be at increased risk for zdv side effects and toxicity. Zidovudine with lamivudine drug bnf content published. Learn about the potential side effects of zidovudine. Zidovudine adverse effects doctor answers on healthcaremagic.
Side effects of retrovir zidovudine, warnings, uses. Comprehensive structured data on known drug adverse effects with. Remain free of side effects including numbness, dizziness, confusion, convulsions, chest pain, syncope and rash. Indications, dose, contraindications, sideeffects, interactions, cautions, warnings and other safety information for zidovudine. These are not all the possible side effects of zidovudine. This is not a complete list of side effects and others may occur. Interferon can cause many different types of sideeffects including anemia, low white blood cell counts, low platelet counts, decreased appetite, tiredness, fatigue and depression. Indications, dose, contraindications, sideeffects, interactions, cautions, warnings and other safety information for zidovudine with lamivudine. In patients with neutrophil counts less than cellsmm. Zidovudine definition of zidovudine by the free dictionary. These sideeffects are usually mild in children taking zidovudine, but if you are worried about any of them, contact your doctor. On ehealthme, you can evaluate side effects and drug interactions from 16 million fda reports.
Zidovudine is an antiviral medicine that prevents human immunodeficiency virus hiv from multiplying in your body. Your doctor may temporarily stop your treatment if you experience serious side effects. Zidovudine azt oral retrovir side effects, medical. Patientfamilyteaching instruct patient to take zidovudine as directed, around the clock, even if sleep is interrupted.
Although zidovudine has no significant effect on the regression of these lesions, it does have antiviral activity in these patients as manifested by a decline in serum human immunodeficiency virus type i antigen. Zidovudine and lamivudine zdv and 3tc are longstanding nucleoside analogreverse transcriptase inhibitors nrtis with extensive clinical experience in a wide spectrum of patients from in utero through childhood and adult ages. Common side effects include headache, feeling tired, nausea, diarrhea, and fever. This article from the emedtv archives explains how the drug works and describes its effects, dosing information, potential side effects, and more. Know zidovudine uses, sideeffects, composition, substitutes, drug interactions, precautions, dosage, warnings only on.
Zidovudine for treatment of hiv infection medicines for children. Zidovudine for the prevention of hiv transmission from mother to infant zidovudine continuedworldwide, perinatal i. Zidovudine side effects, dosage, interactions drugs. Side effects include nausea, weight loss, insomnia, diarrhea, and severe headache. Lamivudinezidovudine, sold under the brand name combivir among others, is a medication used to treat hivaids. Lamivudinezidovudine side effects, dosage, interactions. Emphasize the importance of compliance with therapy, not taking more than prescribed amount, and not discontinuing without consulting health care professional. Retrovir zidovudine, zdv is a drug prescribed for the treatment of the human immunodeficiency virus infection hiv. Zidovudine has been associated with some sideeffects. Side effects have been reported with lamivudine and zidovudine, administered separately or together. Aidsinfo provides the following drug label solely as an example of the labels available for zidovudine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Serious side effects include liver problems, muscle damage, and high blood lactate levels. This study is created by ehealthme based on reports of 9,320 people who have side effects when taking zidovudine from food and drug administration fda, and is updated regularly.
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